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絲氨酸/蘇氨酸激酶36融合同源蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41164R
  • 中文名稱(chēng)：
    絲氨酸/蘇氨酸激酶36融合同源蛋白抗體
  • 英文名稱(chēng)：
    Rabbit anti-STK36 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41164R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,Flow-Cyt,ELISA

  • BN41164R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱(chēng)STK36
中文名稱(chēng)絲氨酸/蘇氨酸激酶36融合同源蛋白抗體
別    名FU antibody Fused homolog; KIAA1278; Serine/threonine kinase 36, fused homolog; STK36_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  激酶和磷酸酶  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量144kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human STK36:21-120/1315 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.

Function:
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.

Subunit:
Interacts with SPAG16 and KIF27 (By similarity).

Subcellular Location:
Cytoplasm. Nucleus. Note=Low levels also present in the nucleus.

Tissue Specificity:
Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 protein kinase domain.

SWISS:
Q9NRP7

Gene ID:
27148

Database links:

Entrez Gene: 27148 Human

Entrez Gene: 269209 Mouse

Entrez Gene: 301516 Rat

Omim: 607652 Human

SwissProt: Q9NRP7 Human

SwissProt: Q69ZM6 Mouse

Unigene: 471404 Human

Unigene: 712986 Human

Unigene: 310974 Mouse

Unigene: 198846 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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