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細胞生長抑制蛋白34
  • 產(chǎn)品貨號：
    BN41162R
  • 中文名稱：
    細胞生長抑制蛋白34
  • 英文名稱：
    Rabbit anti-GIG34 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41162R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41162R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱GIG34
中文名稱細胞生長抑制蛋白34
別    名60S ribosomal protein L11; Cell growth inhibiting protein 34; Cell growth inhibiting protein34; CLL associated antigen KW 12; CLL associated antigen KW12; DBA 7; DBA7; GIG 34; GIG34; Ribosomal protein L11; RPL 11; RL11_HUMAN.  
研究領域腫瘤  細胞生物  免疫學  生長因子和激素  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RPL11/GIG34:101-178/178 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010].

Function:
Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity).

Subunit:
Interacts with PML and MDM2 (By similarity).

Subcellular Location:
Nucleus, nucleolus (By similarity).

DISEASE:
Diamond-Blackfan anemia 7 (DBA7) [MIM:612562]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the ribosomal protein L5P family.

SWISS:
P62913

Gene ID:
6135

Database links:

Entrez Gene: 6135 Human

Entrez Gene: 67025 Mouse

Entrez Gene: 362631 Rat

Omim: 604175 Human

SwissProt: P62913 Human

SwissProt: Q9CXW4 Mouse

SwissProt: P62914 Rat

Unigene: 719951 Human

Unigene: 276856 Mouse

Unigene: 129770 Rat

Unigene: 14687 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.