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RhoC抗體
  • 產品貨號：
    BN41129R
  • 中文名稱：
    RhoC抗體
  • 英文名稱：
    Rabbit anti-RHOC Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41129R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,IF

產品描述

英文名稱RHOC
中文名稱RhoC抗體
別    名ARH 9; ARH9; ARHC; H9; MGC1448; MGC61427; Oncogene RHO H9; Ras homolog gene family member C; RAS related homolog 9; RHO C; Rho cDNA clone 9; Rho related GTP binding protein RhoC; Rho-related GTP-binding protein RhoC; rhoC; RhoC GTPase; RHOC_HUMAN; RHOH 9; RHOH9; Small GTP binding protein RhoC.  
研究領域腫瘤  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, )
產品應用WB=1:500-2000 IHC-P=1:50-100 IHC-F=1:450-100 IF=1:50-100 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human RHOC:1-193/193 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產品介紹This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Function:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.

Subunit:
Interacts with RTKN. Interacts with AKAP13, DIAPH1, PKN2, ROCK1 and ROCK2. Interacts with ARHGDIA.

Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cleavage furrow. Note=Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.

Similarity:
Belongs to the small GTPase superfamily. Rho family.

SWISS:
P08134

Gene ID:
389

Database links:

Entrez Gene: 389 Human

Entrez Gene: 295342 Rat

Omim: 165380 Human

SwissProt: P08134 Human

Unigene: 502659 Human

Unigene: 658289 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.