最近搜索：細胞培養(yǎng) 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>磷酸化自噬微管相關(guān)蛋白輕鏈3抗體
磷酸化自噬微管相關(guān)蛋白輕鏈3抗體
  • 產(chǎn)品貨號：
    BN41111R
  • 中文名稱：
    磷酸化自噬微管相關(guān)蛋白輕鏈3抗體
  • 英文名稱：
    Rabbit anti-phospho-MAP1LC3A (Ser12) Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41111R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Rat(predicted:Mouse,Cow) 推薦應用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱phospho-MAP1LC3A (Ser12)
中文名稱磷酸化自噬微管相關(guān)蛋白輕鏈3抗體
別    名MAP1LC3A(phospho Ser12); MAP1LC3A(phospho S12); ATG8E; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; LC3; LC3A; MAP1 light chain 3 like protein 1; MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; MAP1ALC3; MAP1BLC3; Map1lc3a; Microtubule associated proteins 1A/1B light chain 3; Microtubule-associated protein 1 light chain 3 alpha; Microtubule-associated proteins 1A/1B light chain 3A; MLP3A_HUMAN.   
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域免疫學  信號轉(zhuǎn)導  細胞骨架  線粒體  細胞自噬  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Cow, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量14kDa
細胞定位細胞漿 細胞膜 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human MAP1LC3A around the phosphorylation site of Ser12:RR(p-S)FA 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.

Function:
Involved in formation of autophagosomal vacuoles (autophagosomes).

Subunit:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with SQSTM1 (By similarity). Interacts with TP53INP1 and TP53INP2. Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy.

Subcellular Location:
Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Tissue Specificity:
Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Post-translational modifications:
The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

Similarity:
Belongs to the MAP1 LC3 family.

SWISS:
Q9H492

Gene ID:
84557

Database links:

Entrez Gene: 84557 Human

Entrez Gene: 66734 Mouse

Entrez Gene: 362245 Rat

Omim: 601242 Human

SwissProt: Q9H492 Human

SwissProt: Q91VR7 Mouse

SwissProt: Q6XVN8 Rat

Unigene: 632273 Human

Unigene: 196239 Mouse

Unigene: 3135 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.