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磷酸化gamma氨基丁酸B型受體1抗體
  • 產(chǎn)品貨號：
    BN41079R
  • 中文名稱：
    磷酸化gamma氨基丁酸B型受體1抗體
  • 英文名稱：
    Rabbit anti-phospho-GABBR1 (Ser923) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41079R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應(yīng)用：ELISA

產(chǎn)品描述

英文名稱phospho-GABBR1 (Ser923)
中文名稱磷酸化gamma氨基丁酸B型受體1抗體
別    名GABBR1 (phospho S1180); GABBR1 (phospho Ser1180); p-GABBR1 (Ser1180); GABAb Receptor 1; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GAB B R1; GABA B R1; GABAB R1; GABAB subunit 1c; GABAB(1e); GABABR 1; GABABR1; GABB R1; GABBR 1; GABBR1 3; GABBR1; Gamma aminobutyric acid (GABA) B receptor 1; Gamma aminobutyric acid B receptor 1; Gamma aminobutyric acid type B receptor subunit 1; Gb 1; Gb1; GPRC 3A; GPRC3A; hGB1a; GABR1_HUMAN; Gamma-aminobutyric acid type B receptor subunit 1; GABA B Receptor 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1; Seven transmembrane helix receptor.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域免疫學(xué)  神經(jīng)生物學(xué)  細(xì)胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細(xì)胞定位細(xì)胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human GABBR1 around the phosphorylation site of Ser923:R(p-S)RR 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009].

Function:
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.
Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B-R2 dimerization. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Subunit:
Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity). Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Isoform 1E: Secreted (Probable).

Tissue Specificity:
Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland.

Similarity:
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
Contains 2 Sushi (CCP/SCR) domains.

SWISS:
Q9UBS5

Gene ID:
2550

Database links:

Entrez Gene: 2550 Human

Entrez Gene: 54393 Mouse

Entrez Gene: 81657 Rat

Omim: 603540 Human

SwissProt: Q9UBS5 Human

SwissProt: Q9WV18 Mouse

SwissProt: Q9Z0U4 Rat

Unigene: 167017 Human

Unigene: 32191 Mouse

Unigene: 30059 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

g-氨基丁酸(GABA)是哺乳動物中樞神經(jīng)系統(tǒng)中重要的抑制性神經(jīng)遞質(zhì)，在體內(nèi)通過作用于離子通道型的GABAA、GABAC受體及代謝型的GABAB受體而發(fā)揮生理功能。 GABAB1受體存在于神經(jīng)元的突觸前及突觸后部位，介導(dǎo)慢的抑制性效應(yīng)，在腦內(nèi)參與許多重要的生理活動和病理變化，包括認(rèn)知損害、癲癇、痙攣及藥物成癮等。GABAB受體屬于G蛋白偶聯(lián)受體家族的C家族，具有七次跨膜結(jié)構(gòu)，N-端位于胞外，C-端位于胞內(nèi)。