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蛋白質(zhì)二硫鍵異構(gòu)酶抗體
  • 產(chǎn)品貨號：
    BN41005R
  • 中文名稱：
    蛋白質(zhì)二硫鍵異構(gòu)酶抗體
  • 英文名稱：
    Rabbit anti-PDIA2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41005R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41005R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱PDIA2
中文名稱蛋白質(zhì)二硫鍵異構(gòu)酶抗體
別    名P4HB; Pancreas specific protein disulfide isomerase; Pancreas-specific protein disulfide isomerase; Pancreatic protein disulfide isomerase; PDA2; PDI; PDIA2; PDIA2_HUMAN; PDIP; PDIR; Protein disulfide isomerase A2; Protein disulfide isomerase; Protein disulfide isomerase associated 2; Protein disulfide isomerase family A member 2; Protein disulfide isomerase pancreatic; Protein disulfide-isomerase A2; Rho GDP dissociation inhibitor gamma. 




研究領(lǐng)域腫瘤  細胞生物  免疫學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, )
產(chǎn)品應(yīng)用WB=1:1000-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PDIA2/PDI:431-525/525 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

Function:
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.

Subunit:
Monomer; predominantly as monomer under reducing conditions. Homodimer; disulfide-linked. Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Subcellular Location:
Endoplasmic reticulum lumen.

Tissue Specificity:
Highly expressed in pancreas (at protein level).

Post-translational modifications:
The disulfide-linked homodimer exhibits an enhanced chaperone activity.
Glycosylated.

Similarity:
Belongs to the protein disulfide isomerase family.
Contains 2 thioredoxin domains.

SWISS:
Q13087

Gene ID:
64714

Database links:

Entrez Gene: 100773412 Chinese Hamster

Entrez Gene: 504356 Cow

Entrez Gene: 64714 Human

Entrez Gene: 69191 Mouse

Entrez Gene: 287164 Rat

Omim: 608012 Human

SwissProt: Q13087 Human

SwissProt: D3Z6P0 Mouse

Unigene: 66581 Human

Unigene: 32631 Mouse

Unigene: 65154 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.



















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