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首頁>>免疫學>>一抗>>P21蛋白激活的蛋白激酶6抗體
P21蛋白激活的蛋白激酶6抗體
  • 產(chǎn)品貨號：
    BN40999R
  • 中文名稱：
    P21蛋白激活的蛋白激酶6抗體
  • 英文名稱：
    Rabbit anti-PAK6 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40999R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

  • BN40999R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱PAK6
中文名稱P21蛋白激活的蛋白激酶6抗體
別    名CDKN1A activated kinase 6; Serine/threonine-protein kinase PAK 6; p21 activated protein kinase 6; p21 protein (Cdc42/Rac)-activated kinase 6; p21(CDKN1A) activated kinase 6; p21-ACTIVATED KINASE 6; p21activated kinase 6; PAK 5; PAK 6; PAK5; Serine threonine protein kinase PAK 6; Serine/threonine protein kinase PAK 6; Serine/threonine protein kinase PAK6; EC 2.7.1.37; PAK-5; PAK-6; Pak6; PAK6_HUMAN.  
研究領(lǐng)域腫瘤  免疫學  信號轉(zhuǎn)導  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量75kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PAK6:511-610/681 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.

Function:
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.

Subunit:
Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Interacts with the androgen receptor AR and the estrogen receptor ESR1. Interacts with IQGAP1 and PPM1B.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.

Tissue Specificity:
Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast.

Post-translational modifications:
Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CRIB domain.
Contains 1 protein kinase domain.

SWISS:
Q9NQU5

Gene ID:
56924

Database links:

Entrez Gene: 56924 Human

Omim: 608110 Human

SwissProt: Q9NQU5 Human

Unigene: 513645 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
























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