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半胱氨酸蛋白酶抗體
  • 產(chǎn)品貨號：
    BN40978R
  • 中文名稱：
    半胱氨酸蛋白酶抗體
  • 英文名稱：
    Rabbit anti-Legumain Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40978R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Cow,Horse) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

  • BN40978R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Cow,Horse) 推薦應用：WB,IHC-P,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Legumain
中文名稱半胱氨酸蛋白酶抗體
別    名AEP; Asparaginyl endopeptidase; EC 3.4.22.34; LGMN; LGMN1; Protease, cysteine 1; protease, cysteine, 1 (legumain); PRSC1; LGMN_HUMAN.  
研究領域腫瘤  細胞生物  免疫學  細胞凋亡  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Cow, Horse, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=3ug/Test （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量46kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Legumain:201-300/433 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].

Function:
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.

Subcellular Location:
Lysosome (By similarity).

Tissue Specificity:
Ubiquitous. Particularly abundant in kidney, heart and placenta.

Post-translational modifications:
Glycosylated.

Similarity:
Belongs to the peptidase C13 family.

SWISS:
Q99538

Gene ID:
5641

Database links:

Entrez Gene: 5641 Human

Entrez Gene: 19141 Mouse

Entrez Gene: 63865 Rat

Omim: 602620 Human

SwissProt: Q99538 Human

SwissProt: O89017 Mouse

SwissProt: Q9R0J8 Rat

Unigene: 726036 Human

Unigene: 17185 Mouse

Unigene: 206021 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.