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細胞色素P450 2R1抗體
  • 產(chǎn)品貨號：
    BN40977R
  • 中文名稱：
    細胞色素P450 2R1抗體
  • 英文名稱：
    Rabbit anti-CYP2R1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40977R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40977R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱CYP2R1
中文名稱細胞色素P450 2R1抗體
別    名Cytochrome P450 2R1; Cytochrome P450 family 2 R1; Cytochrome P450 family 2 subfamily R polypeptide 1; EC 1.14.13.15; MGC4663; Vitamin D 25 hydroxylase.  
研究領(lǐng)域腫瘤  心血管  細胞生物  免疫學  信號轉(zhuǎn)導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CYP2R1:251-350/501 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.

Subunit:
Homodimer.

Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue Specificity:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
Q6VVX0

Gene ID:
120227

Database links:

Entrez Gene: 120227 Human

Entrez Gene: 244209 Mouse

Omim: 608713 Human

SwissProt: Q6VVX0 Human

SwissProt: Q6VVW9 Mouse

Unigene: 371427 Human

Unigene: 108037 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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