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嗜中性粒細(xì)胞胞漿因子1抗體
  • 產(chǎn)品貨號(hào)：
    BN40976R
  • 中文名稱：
    嗜中性粒細(xì)胞胞漿因子1抗體
  • 英文名稱：
    Rabbit anti-NCF1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40976R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN40976R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱NCF1
中文名稱嗜中性粒細(xì)胞胞漿因子1抗體
別    名47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF 47K; NCF-1; NCF-47K; Ncf1; NCF1_HUMAN; Neutrophil cytosol factor 1; Neutrophil cytosolic factor 1; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox organizing protein 2; Nox-organizing protein 2; NOXO2; p47 phox; p47-phox; SH3 and PX domain containing protein 1A; SH3 and PX domain-containing protein 1A; SH3PXD1A. 




研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NCF1:151-250/390 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹NCF1, along with NCF2 and a membrane bound cytochrome b558, is required for activation of the latent NADPH oxidase necessary for superoxide production. Defects in NCF1 are the cause of autosomal cytochrome-b-positive chronic granulomatous disease type 1 (CGD).

Function:
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Subunit:
Interacts with NOXA1. Interacts with ADAM15. Interacts with TRAF4. Interacts with FASLG.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylated by PRKCD; phosphorylation induces activation of NCF1 and NADPH oxidase activity.

DISEASE:
Granulomatous disease, chronic, cytochrome-b-positive 1, autosomal recessive (CGD1) [MIM:233700]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 PX (phox homology) domain.
Contains 2 SH3 domains.

SWISS:
P14598

Gene ID:
653361

Database links:

Entrez Gene: 281345 Cow

Entrez Gene: 653361 Human

Entrez Gene: 17969 Mouse

Entrez Gene: 100134857 Pig

Entrez Gene: 100008803 Rabbit

Entrez Gene: 114553 Rat

Omim: 608512 Human

SwissProt: O77774 Cow

SwissProt: P14598 Human

SwissProt: Q09014 Mouse

Unigene: 647047 Human

Unigene: 655201 Human

Unigene: 425296 Mouse

Unigene: 38575 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.