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自噬相關(guān)蛋白4A抗體
  • 產(chǎn)品貨號：
    BN40975R
  • 中文名稱：
    自噬相關(guān)蛋白4A抗體
  • 英文名稱：
    Rabbit anti-ATG4A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40975R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Cow,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN40975R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Cow,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱ATG4A
中文名稱自噬相關(guān)蛋白4A抗體
別    名AI627006 ; APG4 autophagy 4 homolog A ; Apg4a ; ATG4 autophagy related 4 homolog A (S. cerevisiae) ; ATG4 autophagy related 4 homolog A ; ATG4A ; ATG4A_HUMAN ; Atg4al ; AUT like 2 cysteine endopeptidase ; AUT-like 2 cysteine endopeptidase ; Autl2 ; Autophagin 2 ; Autophagin-2 ; Autophagy related 4A cysteine peptidase ; Autophagy related cysteine endopeptidase 2 ; Autophagy related protein 4 homolog A ; Autophagy-related cysteine endopeptidase 2 ; Autophagy-related protein 4 homolog A ; AV169859 ; Cysteine protease ATG4A ; hAPG4A ; MGC107179 .  
研究領(lǐng)域腫瘤  免疫學(xué)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Cow, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ATG4A:51-150/398 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹ATG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Function:
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.

Subcellular Location:
Cytoplasm (Probable).

Tissue Specificity:
Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver.

Similarity:
Belongs to the peptidase C54 family.

SWISS:
Q8WYN0

Gene ID:
115201

Database links:

Entrez Gene: 115201 Human

Entrez Gene: 666468 Mouse

Omim: 300663 Human

SwissProt: Q8WYN0 Human

SwissProt: Q8C9S8 Mouse

Unigene: 8763 Human

Unigene: 102230 Mouse

Unigene: 393320 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.