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胸苷磷酸化酶抗體
  • 產(chǎn)品貨號：
    BN40968R
  • 中文名稱：
    胸苷磷酸化酶抗體
  • 英文名稱：
    Rabbit anti-thymidine phosphorylase Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40968R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40968R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱thymidine phosphorylase
中文名稱胸苷磷酸化酶抗體
別    名ECGF 1; PDEGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Gliostatin; hPD ECGF; MNGIE; PD ECGF; PDECGF; PDEGF; Platelet derived endothelial growth factor; TdRPase; TP; TYMP; Thymidine Phosphorylase; TYPH_HUMAN; TdRPase.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Thymidine Phosphorylase:121-220/482 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Function:
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Subunit:
Homodimer.

DISEASE:
Defects in TYMP are the cause of mitochondrial DNA depletion syndrome type 1 (MTDPS1) [MIM:603041]; also known as myoneurogastrointestinal encephalomyopathy. A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy.

Similarity:
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

SWISS:
P19971

Gene ID:
1890

Database links:

Entrez Gene: 1890 Human

Entrez Gene: 72962 Mouse

Entrez Gene: 315219 Rat

Omim: 131222 Human

SwissProt: P19971 Human

SwissProt: Q99N42 Mouse

SwissProt: Q5FVR2 Rat

Unigene: 180903 Human

Unigene: 730607 Human

Unigene: 287977 Mouse

Unigene: 219088 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胸苷磷酸化酶（TP）是一種分子量為50-55kDa的蛋白，在氟嘧啶轉(zhuǎn)化過程中起重要作用。TP具有血管生成活性，與血小板源性內(nèi)皮細(xì)胞生長因子的結(jié)構(gòu)和作用相似，因此又被稱為腫瘤相關(guān)血管生長因子。其可能通過血管生成作用促進(jìn)癌細(xì)胞的生長和轉(zhuǎn)移。