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磷酸化過氧化酶活化增生受體γ抗體
  • 產品貨號：
    BN40952R
  • 中文名稱：
    磷酸化過氧化酶活化增生受體γ抗體
  • 英文名稱：
    Rabbit anti-Phospho-PPAR Gamma (Ser112) Polyclonal antibody
  • 品牌：
    Biorigin

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    產品規(guī)格

    售價

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  • BN40952R-100ul

    100ul

    ￥2470.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Rabbit,GuineaPig) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產品描述

英文名稱Phospho-PPAR Gamma (Ser112)
中文名稱磷酸化過氧化酶活化增生受體γ抗體
別    名PPAR Gamma (Phospho Ser112); PPAR Gamma (Phospho S112); PPAR Gamma (Phospho-Ser112); CIMT1; HUMPPARG; NR1C3; Nuclear receptor subfamily 1 group C member 3; PAX8/PPARG Fusion Gene; Peroxisome Proliferator Activated Receptor gamma; PPAR gamma; PPARG; PPARG1; PPARG2; PPARG3l; PPARG_HUMAN.  



產品類型磷酸化抗體 
研究領域腫瘤  免疫學  細胞凋亡  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Rabbit, Guinea Pig, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human PPAR Gamma around the phosphorylation site of ser112:PA(p-S)PP 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].

Function:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis.

Subunit:
"Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B. Interacts with PRDM16 (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with DNTTIP2, MAP2K1/MEK1, PRMT2 and TGFB1I1. Interacts with PDPK1. Interacts with ASXL1 AND ASXL2.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.

DISEASE:
Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.
Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
P37231

Gene ID:
5468

Database links:

Entrez Gene: 281993 Cow

Entrez Gene: 403606 Dog

Entrez Gene: 5468 Human

Entrez Gene: 19016 Mouse

Entrez Gene: 397671 Pig

Entrez Gene: 25664 Rat

Omim: 601487 Human

SwissProt: O18971 Cow

SwissProt: Q4U3Q4 Dog

SwissProt: P37231 Human

SwissProt: P37238 Mouse

SwissProt: O62807 Pig

SwissProt: O88275 Rat

Unigene: 162646 Human

Unigene: 3020 Mouse

Unigene: 23443 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

類固醇受體（Steroid Receptors）
過氧化物酶體增殖物激活受體γ（PPARγ）主要存在于白色脂肪組織，PPARγ對于脂肪生成、血糖穩(wěn)定、炎癥反應、動脈粥樣硬化和腫瘤等的發(fā)生都起到重要的作用。主要在脂肪細胞內表達。PPARγ是噻唑烷二酮類藥物（TZDs）作用的藥靶，又是脂肪細胞分化的重要調節(jié)因子。經研究發(fā)現(xiàn)，PPARγ在肥胖及胰島素抵抗的發(fā)病機制中具有十分重要的意義，是治療糖尿病、肥胖等代謝性疾病的重要藥靶。
過氧化物酶體增殖物激活受體γ（PPARγ）屬Ⅱ型核受體超家族成員，主要在脂肪細胞內表達。PPARγ是噻唑烷二酮類藥物（TZDs）作用的藥靶，又是脂肪細胞分化的重要調節(jié)因子?，F(xiàn)有研究（包括一次于美國加州大學進行的研究）發(fā)現(xiàn)PPARγ在肥胖及胰島素抵抗的發(fā)病機制中具有十分重要的意義，是治療糖尿病、肥胖等代謝性疾病的重要藥靶。目前，該受體蛋白質水平的篩選模式已經建立，并正在建立該受體的報告基因的細胞水平篩選評價模式。





























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