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HOXB4抗體
  • 產(chǎn)品貨號：
    BN40942R
  • 中文名稱：
    HOXB4抗體
  • 英文名稱：
    Rabbit anti-HOXB4 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價(jià)

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  • BN40942R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40942R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱HOXB4
中文名稱HOXB4抗體
別    名Homeo box 2F; Homeo box B4; Homeobox 2F; Homeobox B4; Homeobox protein Hox B4; Homeobox protein HoxB4; HOX 2; Hox 2.6; Hox 2F; HOX B4; HOX2; HOX-2 Hox2.6; Hox2F; HOXB 4; HOXB-4.  
研究領(lǐng)域腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HOXB4:151-251/251 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the Antp homeobox family. Deformed subfamily.
Contains 1 homeobox DNA-binding domain.

SWISS:
P17483

Gene ID:
3214

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

OXB4通過激活不同的信號通路增強(qiáng)HSC的自我更新,同時(shí)又不影響維持正常穩(wěn)態(tài)造血的調(diào)控機(jī)制。提高HOXB4的表達(dá)水平,能夠極大地增強(qiáng)HSC的自我更新功能,但基本不影響細(xì)胞的分化、系特異性及終末細(xì)胞的形態(tài)和功能。另外，HOXB4還可增強(qiáng)胚胎干細(xì)胞(embryonic stem cell,ESC)的造血潛能,促進(jìn)ESC向造血細(xì)胞分化。