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親環(huán)蛋白（親環(huán)素）PPIG抗體
  • 產(chǎn)品貨號：
    BN40937R
  • 中文名稱：
    親環(huán)蛋白（親環(huán)素）PPIG抗體
  • 英文名稱：
    Rabbit anti-PPIG Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40937R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA

  • BN40937R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱PPIG
中文名稱親環(huán)蛋白（親環(huán)素）PPIG抗體
別    名CARS cyclophilin; CARS Cyp; CARS-cyclophilin; CARS-Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Clk-associating RS-cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidyl-prolyl cis-trans isomerase G; Peptidyl-prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Ppig; PPIG_HUMAN; Rotamase G; RotamaseG; SCAF10; SR cyclophilin; SR cyp; SR related CTD associated factor 10; SR-cyclophilin; SR-cyp; SRcyp.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量89kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PPIG:351-450/754 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing.

Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.

Subunit:
Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II.

Subcellular Location:
Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 PPIase cyclophilin-type domain.

SWISS:
Q13427

Gene ID:
9360

Database links:

Entrez Gene: 9360 Human

Entrez Gene: 228005 Mouse

Entrez Gene: 83624 Rat

Omim: 606093 Human

SwissProt: Q13427 Human

SwissProt: A2AR02 Mouse

SwissProt: O55035 Rat

Unigene: 727580 Human

Unigene: 11815 Mouse

Unigene: 474951 Mouse

Unigene: 10898 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肽基脯氨?；樂串悩?gòu)酶，廣泛存在于各種組織和器官。根據(jù)對免疫抑制劑的敏感性，分屬三個獨立的家族：親環(huán)蛋白PPIG、FK506結(jié)合蛋白和細(xì)蛋白。能夠加速自身折疊和體內(nèi)新生肽鏈折疊及變性蛋白質(zhì)的體外折疊，主要分布于內(nèi)質(zhì)網(wǎng)。
















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