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磷酸化蛋白激酶樣內(nèi)質(zhì)網(wǎng)激酶抗體
  • 產(chǎn)品貨號：
    BN40896R
  • 中文名稱：
    磷酸化蛋白激酶樣內(nèi)質(zhì)網(wǎng)激酶抗體
  • 英文名稱：
    Rabbit anti-Phospho-PERK (Thr980) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40896R-100ul

    100ul

    ￥2470.00

    交叉反應：Rat,Mouse,Human(predicted:Rabbit,Cow,Pig,Dog) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Phospho-PERK (Thr980)
中文名稱磷酸化蛋白激酶樣內(nèi)質(zhì)網(wǎng)激酶抗體
別    名p-PERK(Thr980); PERK(Phospho Thr980); PERK(Phospho T980); HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase.  


產(chǎn)品類型磷酸化抗體 
研究領域腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量119kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from mouse PERK around the phosphorylation site of Thr980:H(p-T)GQ 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010].

Function:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.

Subunit:
Forms dimers with HSPA5/BIP in resting cells. Oligomerizes in ER-stressed cells. Interacts with DNAJC3.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Autophosphorylated.
N-glycosylated.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
Contains 1 protein kinase domain.

SWISS:
Q9Z2B5

Gene ID:
13666

Database links:

Entrez Gene: 9451 Human

Entrez Gene: 13666 Mouse

Entrez Gene: 29702 Rat

Omim: 604032 Human

SwissProt: Q9NZJ5 Human

SwissProt: Q9Z2B5 Mouse

SwissProt: Q9Z1Z1 Rat

Unigene: 591589 Human

Unigene: 247167 Mouse

Unigene: 24897 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.















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