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磷酸化組蛋白去乙?；?抗體
  • 產(chǎn)品貨號：
    BN40881R
  • 中文名稱：
    磷酸化組蛋白去乙?；?抗體
  • 英文名稱：
    Rabbit anti-phospho-HDAC6 (Ser22) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40881R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱phospho-HDAC6 (Ser22)
中文名稱磷酸化組蛋白去乙酰化酶6抗體
別    名HDAC6 (phospho S22); p-HDAC6 (phospho S22); HDAC6 (phospho Ser22); p-HDAC6 (Ser22); HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域腫瘤  免疫學(xué)  發(fā)育生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量134kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human HDAC6 around the phosphorylation site of Ser22:PQ(p-S)PP 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Subunit:
Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

Subcellular Location:
Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Post-translational modifications:
Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.
Contains 1 UBP-type zinc finger.

SWISS:
Q9UBN7

Gene ID:
10013

Database links:

Entrez Gene: 10013 Human

Entrez Gene: 15185 Mouse

Entrez Gene: 84581 Rat

Omim: 300272 Human

SwissProt: Q9UBN7 Human

SwissProt: Q9Z2V5 Mouse

Unigene: 6764 Human

Unigene: 29854 Mouse

Unigene: 13453 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    HDAC6是一種比較獨(dú)特的組蛋白去乙?；福袃蓚€(gè)功能上相互獨(dú)立的HDAC催化結(jié)構(gòu)域。HDAC6可以去乙酰化組蛋白并抑制相關(guān)基因轉(zhuǎn)錄。
    HDAC6可以和微管(microtuble)結(jié)合，可以去乙酰化tubulin，Hsp90和cortactin等。目前發(fā)現(xiàn)大量的蛋白可以被乙?；揎棧虼薍DAC等乙?；揎椕副徽J(rèn)為在基因轉(zhuǎn)錄調(diào)控、信號轉(zhuǎn)導(dǎo)、生長發(fā)育、分化凋亡、代謝性疾病和腫瘤等多種生理病理過程中發(fā)揮重要作用。HDAC的抑制劑目前被認(rèn)為是很有前景的腫瘤治療藥物。
    內(nèi)源性HDAC6主要定位于細(xì)胞漿，與微管相結(jié)合并且是一個(gè)微管蛋白去乙?；?。HDAC6含有一個(gè)鋅指結(jié)構(gòu)域，該結(jié)構(gòu)域可能和泛素化降解的調(diào)節(jié)有關(guān)。HDAC6可以和DHAC11相互作用。