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組蛋白去乙?；?抗體
  • 產(chǎn)品貨號：
    BN40834R
  • 中文名稱：
    組蛋白去乙酰化酶6抗體
  • 英文名稱：
    Rabbit anti-HDAC6 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

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  • BN40834R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40834R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱HDAC6
中文名稱組蛋白去乙?；?抗體
別    名HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
研究領(lǐng)域腫瘤  發(fā)育生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量134kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HDAC6:301-400/1215 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Subunit:
Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

Subcellular Location:
Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Post-translational modifications:
Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.
Contains 1 UBP-type zinc finger.

SWISS:
Q9UBN7

Gene ID:
10013

Database links:

Entrez Gene: 10013 Human

Entrez Gene: 15185 Mouse

Entrez Gene: 84581 Rat

Omim: 300272 Human

SwissProt: Q9UBN7 Human

SwissProt: Q9Z2V5 Mouse

Unigene: 6764 Human

Unigene: 29854 Mouse

Unigene: 13453 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

 組蛋白去乙酰化酶(HDACs)是一組在細胞染色質(zhì)水平、通過誘導(dǎo)組蛋白去乙?；瘉碚{(diào)控包括染色質(zhì)重組、轉(zhuǎn)錄活化或抑制、細胞周期、細胞分化及細胞凋亡等一系列生物學(xué)效應(yīng)的酶，特別是與細胞活化后的基因轉(zhuǎn)錄表達調(diào)控有關(guān)。
    HDAC6是一種比較獨特的組蛋白去乙酰化酶，含有兩個功能上相互獨立的HDAC催化結(jié)構(gòu)域。HDAC6可以去乙酰化組蛋白并抑制相關(guān)基因轉(zhuǎn)錄。
    HDAC6可以和微管(microtuble)結(jié)合，可以去乙酰化tubulin，Hsp90和cortactin等。目前發(fā)現(xiàn)大量的蛋白可以被乙酰化修飾，因此HDAC等乙酰化修飾酶被認(rèn)為在基因轉(zhuǎn)錄調(diào)控、信號轉(zhuǎn)導(dǎo)、生長發(fā)育、分化凋亡、代謝性疾病和腫瘤等多種生理病理過程中發(fā)揮重要作用。HDAC的抑制劑目前被認(rèn)為是很有前景的腫瘤治療藥物。
    內(nèi)源性HDAC6主要定位于細胞漿，與微管相結(jié)合并且是一個微管蛋白去乙?；浮DAC6含有一個鋅指結(jié)構(gòu)域，該結(jié)構(gòu)域可能和泛素化降解的調(diào)節(jié)有關(guān)。HDAC6可以和DHAC11相互作用。