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Bcr抗體
  • 產(chǎn)品貨號：
    BN40829R
  • 中文名稱：
    Bcr抗體
  • 英文名稱：
    Rabbit anti-Bcr Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40829R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

  • BN40829R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Bcr
中文名稱Bcr抗體
別    名ALL; BCR 1; BCR/ABL FUSION GENE INCLUDED; BCR/FGFR1 FUSION GENE INCLUDED; BCR/PDGFRA FUSION GENE INCLUDED; BCR1; breakpoint cluster region; CML; PHL; BCR_HUMAN.  
研究領域免疫學  細胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量143kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Bcr:1201-1271/1271 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.

Function:
GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.

Subunit:
Homotetramer. Interacts with PDZK1. May interact with CCPG1. Interacts with FES/FPS, ABL1, PIK3R1 and GRB2. Interacts with HCK.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Autophosphorylated. Phosphorylated by FES/FPS on tyrosine residues, leading to down-regulation of the BCR kinase activity. Phosphorylation at Tyr-177 by HCK is important for interaction with GRB2.

DISEASE:
Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Similarity:
Contains 1 C2 domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 Rho-GAP domain.

SWISS:
P11274

Gene ID:
613

Database links:

Entrez Gene: 613 Human

Omim: 151410 Human

SwissProt: P11274 Human

Unigene: 517461 Human

Unigene: 715409 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.