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白介素15受體α抗體
  • 產(chǎn)品貨號：
    BN40825R
  • 中文名稱：
    白介素15受體α抗體
  • 英文名稱：
    Rabbit anti-IL15RA Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40825R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

  • BN40825R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Cow,Horse,Rabbit) 推薦應用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱IL15RA
中文名稱白介素15受體α抗體
別    名Interleukin-15 receptor subunit alpha; IL 15R alpha; IL15RA; IL-15RA; Interleukin 15 receptor alpha; Interleukin 15 receptor subunit alpha; Soluble interleukin 15 receptor subunit alpha; I15RA_HUMAN.  
研究領域免疫學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
細胞定位細胞核 細胞漿 細胞膜 細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IL-15RA:51-150/267 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹IL15RA is a cytokine receptor that specifically binds IL15 with high affinity. It shares two subunits with the receptor of IL2, the IL2R beta and IL2R gamma chains. This forms the basis of many overlapping biological activities of IL15 and IL2. The IL2 receptor requires an additional IL2-specific alpha subunit for high affinity IL2 binding. This protein is structurally related to IL2R alpha, but is capable of binding IL15 with high affinity independent of other subunits, which suggests the distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. There are nine different isoforms.

Function:
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.

Subunit:
The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.

Subcellular Location:
Membrane. Nucleus membrane; Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space.

Tissue Specificity:
Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.

Post-translational modifications:
A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Phosphorylated by activated SYK.
N-glycosylated and O-glycosylated.

Similarity:
Contains 1 Sushi (CCP/SCR) domain.

SWISS:
Q13261

Gene ID:
3601

Database links:

Entrez Gene: 3601 Human

Omim: 601070 Human

SwissProt: Q13261 Human

Unigene: 524117 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications