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G蛋白結(jié)合蛋白RAB6A抗體
  • 產(chǎn)品貨號：
    BN40814R
  • 中文名稱：
    G蛋白結(jié)合蛋白RAB6A抗體
  • 英文名稱：
    Rabbit anti-RAB6A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40814R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB

  • BN40814R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB

產(chǎn)品描述

英文名稱RAB6A
中文名稱G蛋白結(jié)合蛋白RAB6A抗體
別    名GTP binding protein RAB6B; Oncogene RAB6; Rab GTPase; Rab6A variant 3; Rab 6; RAB6; RAB6 member RAS oncogene family; RAB6A member RAS oncogene family; Ras related protein Rab 6A; RCO4 3; RAB6A_MOUSE.  
研究領(lǐng)域信號轉(zhuǎn)導  G蛋白偶聯(lián)受體  G蛋白信號  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse RAB6A:141-208/280 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves, at each stage, the movement of carrier vesicles; a process that appears to involve Rab protein function. The possibility that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the Sec4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab subfamily have been identified, each of which is found at a particular stage of a membrane transport pathway. Rab 6, also known as RAB6B, RAB6A or RAB6A, is a 208 amino acid protein that is ubiquitously expressed and is a member of the small GTPase superfamily.

Function:
RAB6A belongs to the small GTPase superfamily. It may be involved in protein transport. It is a regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) and has a low GTPase activity.

Subunit:
Interacts with CCDC64; leads to its accumulation in the pericentrosomal region (By similarity). Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Interacts with GCC2 (via its GRIP domain). Interacts with RAB6IP1 (via its RUN 1 domain). Isoform 1 interacts with RAB6KIFL. Isoform 2 does not interact with RAB6KIFL. Isoform 1 interacts with BICD1. Isoform 2 interacts with BICD1. Isoform 1 interacts with BICD2. Isoform 2 interacts with BICD2. Interacts with TMF1. Isoform 1 (GTP-bound) interacts with DYNLRB1; the interaction is direct. Isoform 2 (GDP-bound) interacts with DYNLRB1; the interaction is direct. Interacts with PIFO.

Subcellular Location:
Golgi apparatus membrane; Lipid-anchor.

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the small GTPase superfamily. Rab family.

SWISS:
P34279

Gene ID:
19346

Database links:

Entrez Gene: 5870 Human

Entrez Gene: 19346 Mouse

Entrez Gene: 84379 Rat

Omim: 179513 Human

SwissProt: P20340 Human

SwissProt: P35279 Mouse

SwissProt: Q9WVB1 Rat

Unigene: 503222 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


















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