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環(huán)指蛋白43抗體
  • 產(chǎn)品貨號(hào)：
    BN40812R
  • 中文名稱：
    環(huán)指蛋白43抗體
  • 英文名稱：
    Rabbit anti-RNF43 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40812R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P

  • BN40812R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P

產(chǎn)品描述

英文名稱RNF43
中文名稱環(huán)指蛋白43抗體
別    名RNF124; Ring finger protein 43; URCC; RNF43_HUMAN; E3 ubiquitin-protein ligase RNF43; RING finger protein 43.  
研究領(lǐng)域腫瘤  細(xì)胞生物  腫瘤細(xì)胞生物標(biāo)志物  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:400-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量83kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human RNF43:401-500/783 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹RNF43 is a probable E3 ubiquitin-protein ligase that promotes cell growth and is upregulated in colon cancer. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Function:
Probable E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Subunit:
Interacts with AKAP8L, NONO and SFPQ.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Nucleus envelope.

Tissue Specificity:
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.

Similarity:
Contains 1 RING-type zinc finger.

SWISS:
Q68DV7

Gene ID:
54894

Database links:

Entrez Gene: 54894 Human

Entrez Gene: 207742 Mouse

Entrez Gene: 303412 Rat

Omim: 612482 Human

SwissProt: Q68DV7 Human

SwissProt: Q5NCP0 Mouse

Unigene: 584916 Human

Unigene: 440230 Mouse

Unigene: 214174 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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