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組織胺H3受體抗體
  • 產品貨號：
    BN40778R
  • 中文名稱：
    組織胺H3受體抗體
  • 英文名稱：
    Rabbit anti-HRH3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN40778R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Cow,Horse,Sheep) 推薦應用：WB,ELISA

  • BN40778R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Cow,Horse,Sheep) 推薦應用：WB,ELISA

產品描述

英文名稱HRH3
中文名稱組織胺H3受體抗體
別    名G protein coupled receptor 97; GPCR 97; GPCR97; H3R; HH 3R; HH3 R; HH3R; Histamine H3 receptor; Histamine receptor H3; HRH 3; HRH3; HRH-3.  
研究領域腫瘤  細胞生物  免疫學  信號轉導  轉錄調節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Cow, Horse, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HRH3:281-380/445 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008].

Function:
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q9Y5N1

Gene ID:
11255

Database links:

Entrez Gene: 11255 Human

Entrez Gene: 99296 Mouse

Entrez Gene: 85268 Rat

Omim: 604525 Human

SwissProt: Q9Y5N1 Human

SwissProt: P58406 Mouse

SwissProt: Q9QYN8 Rat

Unigene: 251399 Human

Unigene: 285360 Mouse

Unigene: 7617 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications