最近搜索：細(xì)胞培養(yǎng) 微生物學(xué) 分子生物 生物化學(xué)
首頁>>免疫學(xué)>>一抗>>胚胎干細(xì)胞關(guān)鍵蛋白抗體
胚胎干細(xì)胞關(guān)鍵蛋白抗體
  • 產(chǎn)品貨號：
    BN40762R
  • 中文名稱：
    胚胎干細(xì)胞關(guān)鍵蛋白抗體
  • 英文名稱：
    Rabbit anti-SOX2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40762R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse(predicted:Sheep,Horse,Cow,Dog,Chicken,Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN40762R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse(predicted:Sheep,Horse,Cow,Dog,Chicken,Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱SOX2
中文名稱胚胎干細(xì)胞關(guān)鍵蛋白抗體
別    名transcriptional factor SOX2; ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MGC148683; MGC2413; RGD1565646; Sex determining region Y box 2; Sex determining region Y-box 2; SOX 2; SRY (sex determining region Y) box 2; SRY box containing gene 2; SRY related HMG box 2; SRY related HMG box gene 2; SRY-box 2; ysb; SOX2_HUMAN; Transcription factor SOX-2; SOX2_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  干細(xì)胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SOX2:1-100/317 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008].

Function:
Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.

Subunit:
Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.

DISEASE:
Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia, and esophageal atresia with trachoesophageal fistula.

Similarity:
Contains 1 HMG box DNA-binding domain.

SWISS:
P48431

Gene ID:
6657

Database links:

Entrez Gene: 6657 Human

Entrez Gene: 20674 Mouse

Omim: 184429 Human

SwissProt: P48431 Human

SwissProt: P48432 Mouse

Unigene: 518438 Human

Unigene: 65396 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Embryonic Stem Cell Marker (胚胎干細(xì)胞標(biāo)志物)
轉(zhuǎn)錄因子:胚胎干細(xì)胞相關(guān)蛋白Sox2是sox基因家族的一個成員,Sox2與Oct4、Nanog一樣是胚胎干細(xì)胞重要的轉(zhuǎn)錄因子，是維持干細(xì)胞特性中起到重要的作用因子；由于它在早期胚胎發(fā)生、神經(jīng)分化和晶狀體發(fā)育等多種重要的發(fā)育事件中都起著關(guān)鍵的作用,從而引起了越來越廣泛的關(guān)注。