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CD163抗體
  • 產品貨號：
    BN40757R
  • 中文名稱：
    CD163抗體
  • 英文名稱：
    Rabbit anti-CD163 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN40757R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,ELISA

  • BN40757R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,ELISA

產品描述

英文名稱CD163
中文名稱CD163抗體
別    名Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN.  
研究領域心血管  免疫學  細胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量121kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD163:551-650/1156 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.

Function:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Subcellular Location:
Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Tissue Specificity:
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Post-translational modifications:
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.

Similarity:
Contains 9 SRCR domains.

SWISS:
Q86VB7

Gene ID:
9332

Database links:

Entrez Gene: 9332 Human

Entrez Gene: 93671 Mouse

Entrez Gene: 312701 Rat

Omim: 605545 Human

SwissProt: Q86VB7 Human

SwissProt: Q2VLH6 Mouse

Unigene: 504641 Human

Unigene: 37426 Mouse

Unigene: 203204 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD163是SRCR超家族成員之一，又稱為血紅蛋白清道夫受體（hemoglobin scavenger receptor, HbSR）、M130或p155。CD163的表達水平受很多因素調節(jié)，糖皮質激素及抗炎介質如IL-10以及IL-6能上調CD163, 而促炎介質如脂多糖（lipopolysaccharide, LPS）、γ-干擾素（interferon-γ， IFN-γ）以及TNF-α則抑制CD163表達。 CD163是一種I型膜蛋白，又稱為M130抗原、Ber-Mac3、Ki-M8或SM4。CD163限制性表達于單核/巨噬細胞系，所有循環(huán)系統的單核細胞和大多數組織（除外淋巴濾泡套區(qū)和生發(fā)中心）的巨噬細胞均陽性表達，主要用于單核/巨噬細胞的檢測。