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叉頭蛋白P3抗體
  • 產(chǎn)品貨號(hào)：
    BN40751R
  • 中文名稱：
    叉頭蛋白P3抗體
  • 英文名稱：
    Rabbit anti-FoxP3 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40751R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,ICC,Flow-Cyt,ELISA

  • BN40751R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,ICC,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱FoxP3
中文名稱叉頭蛋白P3抗體
別    名AIID; AIID; DIETER; DIETER; Forkhead box P3; Forkhead box protein P3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; IPEX; JM2; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; PIDX; SCURFIN; SCURFIN; XPID; XPID.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細(xì)胞  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量47kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FoxP3:351-431/431 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:
Probable transcription factor. Plays a critical role in the control of immune response.

Subunit:
Interacts with IKZF3.

Subcellular Location:
Nucleus (Potential).

Post-translational modifications:
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.

DISEASE:
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.

Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.

SWISS:
Q9BZS1

Gene ID:
50943

Database links:

Entrez Gene: 50943 Human

Entrez Gene: 20371 Mouse

Entrez Gene: 317382 Rat

Omim: 300292 Human

SwissProt: Q9BZS1 Human

SwissProt: Q99JB6 Mouse

SwissProt: D3ZKI1 Rat

Unigene: 247700 Human

Unigene: 182291 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

叉頭蛋白3(FOXP3)是FOX蛋白家族成員之一,主要為T(mén)細(xì)胞轉(zhuǎn)錄蛋白，主要表達(dá)于T細(xì)胞+CD4+CD25,并調(diào)節(jié)該類T細(xì)胞的發(fā)育和功能.
FOXP3的表達(dá)受轉(zhuǎn)化生長(zhǎng)因子-β雌激素和糖皮質(zhì)激素等調(diào)節(jié),通過(guò)競(jìng)爭(zhēng)性抑制活化T細(xì)胞核因子的轉(zhuǎn)錄活性而發(fā)揮作用.自身免疫性糖尿病患者體內(nèi)CD4+CD25+T細(xì)胞減少,誘導(dǎo)FOXP3的表達(dá)或過(guò)繼轉(zhuǎn)移CD4+CD25+T細(xì)胞有可能預(yù)防自身免疫性糖尿病

















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