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半胱胺酸蛋白酶蛋白-12抗體
  • 產(chǎn)品貨號(hào)：
    BN40743R
  • 中文名稱：
    半胱胺酸蛋白酶蛋白-12抗體
  • 英文名稱：
    Rabbit anti-Caspase-12 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40743R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40743R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Caspase-12
中文名稱半胱胺酸蛋白酶蛋白-12抗體
別    名Caspase-12; UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene); Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415.  
研究領(lǐng)域細(xì)胞生物  細(xì)胞凋亡  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Caspase-12:21-100/341 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]

Function:
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.

Tissue Specificity:
Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Similarity : Belongs to the peptidase C14A family.

Similarity:
Belongs to the peptidase C14A family.
Contains 1 CARD domain.

SWISS:
Q6UXS9

Gene ID:
100506742

Database links:

Entrez Gene: 100506742 Human

SwissProt: Q6UXS9 Human

Unigene: 476989 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ASPASE-12是caspase家族成員，是存在于內(nèi)質(zhì)網(wǎng)上的促凋亡因子，內(nèi)質(zhì)網(wǎng)應(yīng)激早期可通過GRP（glucose-regulated protein，GRP）的表達(dá)增多來保護(hù)細(xì)胞；CASPASE-12是內(nèi)質(zhì)網(wǎng)細(xì)胞關(guān)鍵介導(dǎo)因子，caspase-12還是caspase-1的抑制劑。