最近搜索：細胞培養(yǎng) 微生物學 分子生物 生物化學
首頁>>免疫學>>一抗>>端粒結(jié)合蛋白2抗體
端粒結(jié)合蛋白2抗體
  • 產(chǎn)品貨號：
    BN40735R
  • 中文名稱：
    端粒結(jié)合蛋白2抗體
  • 英文名稱：
    Rabbit anti-TRF2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40735R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat 推薦應用：WB

  • BN40735R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat 推薦應用：WB

產(chǎn)品描述

英文名稱TRF2
中文名稱端粒結(jié)合蛋白2抗體
別    名Telomeric DNA binding protein; Telomeric repeat binding factor 2; Telomeric repeat binding protein 2; TERF 2; TERF2; TRBF 2; TRBF2; TRF 2; TTAGGG repeat binding factor 2.  
研究領域腫瘤  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Rat, 
產(chǎn)品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TRF2:251-350/500 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]

Function:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.

Subcellular Location:
Nucleus. Chromosome, telomere. Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.

Tissue Specificity:
Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes. Post-translational modifications : Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 HTH myb-type DNA-binding domain.

SWISS:
Q15554

Gene ID:
7014

Database links:

Entrez Gene: 7014 Human

Entrez Gene: 21750 Mouse

Entrez Gene: 361403 Rat

Omim: 602027 Human

SwissProt: Q15554 Human

SwissProt: O35144 Mouse

Unigene: 63335 Human

Unigene: 6402 Mouse

Unigene: 35087 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications






















image.png