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PEG3蛋白抗體
  • 產(chǎn)品貨號：
    BN40717R
  • 中文名稱：
    PEG3蛋白抗體
  • 英文名稱：
    Rabbit anti-PEG3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40717R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human 推薦應(yīng)用：IHC-P

  • BN40717R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human 推薦應(yīng)用：IHC-P

產(chǎn)品描述

英文名稱PEG3
中文名稱PEG3蛋白抗體
別    名Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24; Kruppel-type zinc finger protein; paternally expressed 3; Paternally expressed gene 3; PEG3 protein; Pw1; Zn-finger protein Pw1; PEG3_HUMAN; Paternally-expressed gene 3 protein.  
研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量175kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PEG3:1011-1110/1588 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Function:
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.

Subunit:
Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 12 C2H2-type zinc fingers.
Contains 1 SCAN box domain.

SWISS:
Q9GZU2

Gene ID:
18616

Database links:

Entrez Gene: 18616 Mouse

Entrez Gene: 66549 Mouse

Entrez Gene: 246361 Rat

SwissProt: O54978 Mouse

SwissProt: Q3URU2 Mouse

SwissProt: Q61138 Mouse

SwissProt: Q6GQS0 Mouse

SwissProt: Q8R5N0 Mouse

SwissProt: Q9QX53 Mouse

Unigene: 7952 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PEG3蛋白是一種轉(zhuǎn)錄因子。在胰腺、腦組織、胎盤、卵巢、睪丸等組織中表達(dá)，PEG3蛋白位于細(xì)胞核內(nèi)。PEG3也是一個(gè)凋亡促進(jìn)因子并可能參與調(diào)節(jié)腫瘤壞死因子(TNF)信號傳導(dǎo)通路。


















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