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基質(zhì)金屬蛋白酶-9抗體
  • 產(chǎn)品貨號：
    BN40698R
  • 中文名稱：
    基質(zhì)金屬蛋白酶-9抗體
  • 英文名稱：
    Rabbit anti-MMP9 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40698R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Cow,Horse,Rabbit,Sheep) 推薦應用：WB

  • BN40698R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Cow,Horse,Rabbit,Sheep) 推薦應用：WB

產(chǎn)品描述

英文名稱MMP9
中文名稱基質(zhì)金屬蛋白酶-9抗體
別    名Matrix metalloproteinase-9 precursor; MMP-9; MMP9; MMP 9; 92 kDa type IV; Collagenase; 92 kDa gelatinase; Gelatinase B; GELB; MMP9_HUMAN; 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG-4B; CLG4B; Collagenase Type 4 beta; Collagenase Type-4 beta; Collagenase type IV 92 KD; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase 92 KD; Gelatinase beta; Gelatinase-beta; GelatinaseB; GELB; Macrophage gelatinase; MANDP2; Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix Metalloproteinase 9; Type V collagenase.  
研究領(lǐng)域腫瘤  細胞生物  神經(jīng)生物學  信號轉(zhuǎn)導  細胞凋亡  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量78kDa
細胞定位細胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MMP9:231-330/707 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

Function:
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

Subunit:
Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tissue Specificity:
Produced by normal alveolar macrophages and granulocytes.

Post-translational modifications:
Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.

DISEASE:
Defects in MMP9 are the cause of metaphyseal anadysplasia type 2 (MANDP2) [MIM:613073]. Metaphyseal anadysplasia consists of an abnormal bone development characterized by severe skeletal changes that, in contrast with the progressive course of most other skeletal dysplasias, resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia.

Similarity:
Belongs to the peptidase M10A family.
Contains 3 fibronectin type-II domains.
Contains 4 hemopexin-like domains.

SWISS:
P14780

Gene ID:
4318

Database links:
Entrez Gene: 403885 Dog

Entrez Gene: 4318 Human

Entrez Gene: 17395 Mouse

Entrez Gene: 81687 Rat

Omim: 120361 Human

SwissProt: O18733 Dog

SwissProt: P14780 Human

SwissProt: P41245 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

合成與降解（Synthesis and Degradation）

MMP9亦稱IV型膠原酶或明膠酶B，其主要功能為降解IV型膠原。因而它在腫瘤細胞突破基底膜屏障和浸潤轉(zhuǎn)移中起重要作用。
目前主要用于各種惡性腫瘤(如乳腺癌、胃腸道癌、卵巢癌、膀胱癌等)中的基底膜檢測與轉(zhuǎn)移浸潤的研究。細胞外基質(zhì)在維持正常組織結(jié)構(gòu)與功能以及細胞生長和分化過程中起重要作用。細胞外基質(zhì)動態(tài)平衡的失調(diào)與腫瘤細胞侵襲、轉(zhuǎn)移和復發(fā)密切相關(guān)，基質(zhì)金屬蛋白酶(MMP-9)是細胞外基質(zhì)的降解酶，可降解Ⅳ、Ⅴ、Ⅸ、Ⅺ型膠原，在腫瘤的浸潤、轉(zhuǎn)移過程中起重要作用，近年為腫瘤研究的熱點。



Kiss-1與MMP-9、MMP-2 是轉(zhuǎn)移浸潤研究的熱門課題。