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褪黑素受體1A/松果體素受體1A抗體
  • 產(chǎn)品貨號：
    BN40670R
  • 中文名稱：
    褪黑素受體1A/松果體素受體1A抗體
  • 英文名稱：
    Rabbit anti-Melatonin Receptor 1A Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40670R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow,Sheep) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN40670R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow,Sheep) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Melatonin Receptor 1A
中文名稱褪黑素受體1A/松果體素受體1A抗體
別    名Mel 1A R; Mel1a melatonin receptor; Mel1a receptor; MEL-1A-R; Melatonin receptor type 1A; MelR; MR; MT 1; MT1; MTNR 1A; MTNR1A; Melatonin receptor 1A; MTR1A_HUMAN; MTR-1A.  
研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞膜受體  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Cow, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Melatonin Receptor 1A :181-280/350 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

Function:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P48039

Gene ID:
4543

Database links:
Entrez Gene: 4543 Human

Omim: 600665 Human

SwissProt: P48039 Human

Unigene: 243467 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

褪黑激素受體1A- 此抗體是MTR-1A特異性抗體，與MTR-1B無交叉反應(yīng)。MEL-1A-R除分布在視網(wǎng)膜和下丘腦外，還廣泛存在于多個組織中，也是有重著要生理活性的激素。