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腦轉(zhuǎn)錄因子4蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN40646R
  • 中文名稱：
    腦轉(zhuǎn)錄因子4蛋白抗體
  • 英文名稱：
    Rabbit anti-BRN4 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40646R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40646R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：nan(predicted:Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱BRN4
中文名稱腦轉(zhuǎn)錄因子4蛋白抗體
別    名class 3; transcription factor 4; Brain specific homeobox POU domain protein 4; Brain-4; Brain-specific homeobox/POU domain protein 4; BRAIN4; Brn-4; BRN4; DFN3; Oct-9; Octamer-binding protein 9; Octamer-binding transcription factor 9; OTF-9; OTF9; PO3F4_HUMAN; POU domain; POU domain class 3 transcription factor 4; POU3F4.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BRN4:1-100/361 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.Defects in POU3F4 are a cause of deafness X-linked type 2 (DFNX2) . A mixed type of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation and progressive sensorineural deafness.

Function:
Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain.

Subunit:
Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.

Subcellular Location:
Nucleus.

Tissue Specificity:
Brain specific.

DISEASE:
Defects in POU3F4 are a cause of deafness X-linked type 2 (DFNX2) [MIM:304400]. A mixed type of deafness characterized by both conductive hearing loss resulting from stapes (perilymphatic gusher) fixation and progressive sensorineural deafness.

Similarity:
Belongs to the POU transcription factor family. Class-3 subfamily.
Contains 1 homeobox DNA-binding domain.
Contains 1 POU-specific domain.

SWISS:
P49335

Gene ID:
5456

Database links:

Entrez Gene: 5456 Human

Entrez Gene: 18994 Mouse

Entrez Gene: 29589 Rat

Omim: 300039 Human

SwissProt: P49335 Human

SwissProt: P62515 Mouse

SwissProt: P62516 Rat

Unigene: 2229 Human

Unigene: 405149 Mouse

Unigene: 56946 Mouse

Unigene: 33030 Rat

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.













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