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胰島素受體底物-2抗體
  • 產品貨號：
    BN40643R
  • 中文名稱：
    胰島素受體底物-2抗體
  • 英文名稱：
    Rabbit anti-IRS-2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN40643R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat(predicted:Mouse,Horse) 推薦應用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN40643R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat(predicted:Mouse,Horse) 推薦應用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產品描述

英文名稱IRS-2
中文名稱胰島素受體底物-2抗體
別    名Insulin Receptor Substrate 2; IRS 2; IRS-2; IRS2; IRS2_HUMAN.  
研究領域細胞生物  神經生物學  信號轉導  細胞凋亡  細胞膜受體  糖尿病  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Horse, )
產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量146kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IRS-2:461-560/1338 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

Function:
May mediate the control of various cellular processes by insulin.

Subunit:
Interacts with PHIP.

Subcellular Location:
Cytoplasm, cytosol.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

SWISS:
Q9Y4H2

Gene ID:
8660

Database links:

Entrez Gene: 8660 Human

Entrez Gene: 384783 Mouse

Entrez Gene: 29376 Rat

Omim: 600797 Human

SwissProt: Q9Y4H2 Human

SwissProt: P81122 Mouse

Unigene: 442344 Human

Unigene: 407207 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IRS-2是肝胰島素信號轉導核心介子，IRS-2基因的缺失或IRS-2信號網絡上一些關鍵信號分子的異常改變，都將導致肝胰島素信號轉導能力減弱，出現肝胰島素抵抗.












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