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B7-H4抗體
  • 產(chǎn)品貨號(hào)：
    BN40634R
  • 中文名稱：
    B7-H4抗體
  • 英文名稱：
    Rabbit anti-B7H4 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN40634R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN40634R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Dog,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱B7H4
中文名稱B7-H4抗體
別    名B7-H4; B7h4; B7S1; B7x; BC032925; Immune costimulatory protein B7H4; MGC41287; PRO1291; T cell costimulatory molecule B7x; V set domain-containing T cell activation inhibitor 1; VCTN1; VTCN1_HUMAN.  
研究領(lǐng)域腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human B7H4:101-200/282 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

Function:
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Subcellular Location:
cell membrane; Single-pass type I membrane protein (Potential). Note=Expressed at the cell surface. A soluble form has also been detected.

Tissue Specificity:
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 2 Ig-like V-type (immunoglobulin-like) domains.

SWISS:
Q7Z7D3

Gene ID:
79679

Database links:

Entrez Gene: 79679 Human

Entrez Gene: 242122 Mouse

Entrez Gene: 295322 Rat

Omim: 608162 Human

SwissProt: Q7Z7D3 Human

SwissProt: Q7TSP5 Mouse

SwissProt: Q501W4 Rat

Unigene: 546434 Human

Unigene: 137467 Mouse

Unigene: 160956 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

B7-H4(B7 Homolog 4)是B7家族中的新成員,它能通過抑制T細(xì)胞的增殖、細(xì)胞因子的產(chǎn)生和細(xì)胞周期的進(jìn)程來負(fù)性調(diào)控T細(xì)胞的免疫應(yīng)答,其大量表達(dá)B7-H4還可以促進(jìn)上皮細(xì)胞的惡性轉(zhuǎn)化,保護(hù)表皮細(xì)胞免于失巢凋亡,在腫瘤的發(fā)生,進(jìn)展和轉(zhuǎn)歸中發(fā)揮重要作用.
目前對B7-H4信號(hào)通路的進(jìn)一步的研究必將為自身免疫性疾病、病毒感染性疾病和器官移植后排斥反應(yīng)中T細(xì)胞介導(dǎo)的免疫應(yīng)答調(diào)控提供了新的途徑,同時(shí)也為腫瘤的診斷、治療提供嶄新的前景。





















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