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甘氨酸受體β/GlyR β抗體
  • 產(chǎn)品貨號：
    BN40601R
  • 中文名稱：
    甘氨酸受體β/GlyR β抗體
  • 英文名稱：
    Rabbit anti-GLRB Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40601R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

  • BN40601R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF

產(chǎn)品描述

英文名稱GLRB
中文名稱甘氨酸受體β/GlyR β抗體
別    名Glycine receptor 58 kDa subunit; Glycine receptor beta; Glycine receptor subunit beta; Glycine receptor, beta subunit; GLRB_HUMAN.  
研究領(lǐng)域細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  通道蛋白  細胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GLRB:51-150/497 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹GLRB (Glycine receptor beta) is a neurotransmitter-gated ion channel concentrated within the spinal cord and brainstem. Expression is also observed in several upper brain regions including the cortex, cerebellum, hippocampus and amygdala. Binding of glycine to GLRB increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing), controlling spinal reflexes and locomotor behavior.

Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).

Subunit:
Pentamer composed of alpha and beta subunits. Interacts with GPHN

Subcellular Location:
Plasma membrane; multi-pass membrane protein.

DISEASE:
Defects in GLRB are the cause of hyperekplexia type 2 (HKPX2) [MIM:614619]. HKPX2 is a neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile2 stimuli.

Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub-subfamily.

SWISS:
P48167

Gene ID:
2743

Database links:

Entrez Gene: 2743 Human

Entrez Gene: 14658 Mouse

Entrez Gene: 25456 Rat

Omim: 138492 Human

SwissProt: P48167 Human

SwissProt: P48168 Mouse

SwissProt: P20781 Rat

Unigene: 32973 Human

Unigene: 275639 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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