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脂蛋白脂酶抗體
  • 產(chǎn)品貨號：
    BN40572R
  • 中文名稱：
    脂蛋白脂酶抗體
  • 英文名稱：
    Rabbit anti-Lipoprotein lipase Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN40572R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat,Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Cow,Pig) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40572R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat,Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Cow,Pig) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Lipoprotein lipase
中文名稱脂蛋白脂酶抗體
別    名Lipoprotein lipase; LIPD; LIPL_HUMAN; LPL; LPL protein; EC 3.1.1; EC 3.1.1.34; HDLCQ11; LPL; LPL protein; MGC137861.  
研究領域心血管  細胞生物  免疫學  細胞粘附分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Pig, Cow, Rabbit, Sheep, Guinea Pig, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2μg /test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
細胞定位細胞漿 細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LPL:401-475/475 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation.

Function:
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Subunit:
Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.

Tissue Specificity:
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T lymphocytes, neutrophils, monocytes, B lymphocytes, and myeloid cells.

Post-translational modifications:
Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.

DISEASE:
Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.

Similarity:
Belongs to the AB hydrolase superfamily. Lipase family.
Contains 1 PLAT domain.

SWISS:
P06858

Gene ID:
4023

Database links:

Entrez Gene: 280843 Cow

Entrez Gene: 4023 Human

Entrez Gene: 16956 Mouse

Omim: 238600 Human

SwissProt: P11151 Cow

SwissProt: P06858 Human

SwissProt: P11152 Mouse

Unigene: 180878 Human

Unigene: 1514 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

脂蛋白脂酶（lipoprteinlipase，LPL）是甘油三酯降解為甘油和游離脂肪酸 (FFA)反應的限速酶,是脂肪細胞、心肌細胞、骨骼肌細胞、乳腺細胞以及巨噬細胞等實質(zhì)細胞合成和分泌的一種糖蛋白與機體的脂質(zhì)代謝及肥胖與否密切相關. 近年來研究認為：LPL可通過粘附作用，促進了單核細胞血管內(nèi)皮細胞及腫瘤壞死因子（TNF）的分泌、血管平滑肌細胞增殖等因素，導致動脈粥樣硬化的加重。
























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