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酪氨酸蛋白磷酸酶非受體型12抗體
  • 產(chǎn)品貨號(hào)：
    BN40568R
  • 中文名稱(chēng)：
    酪氨酸蛋白磷酸酶非受體型12抗體
  • 英文名稱(chēng)：
    Rabbit anti-PTPN12 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40568R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

  • BN40568R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱(chēng)PTPN12
中文名稱(chēng)酪氨酸蛋白磷酸酶非受體型12抗體
別    名Protein tyrosine phosphatase G1; Protein tyrosine phosphatase non receptor type 12; Protein-tyrosine phosphatase G1; PTN12_HUMAN; PTP PEST; PTP-PEST; PTPG1; Ptpn12; Tyrosine protein phosphatase non receptor type 12; Tyrosine-protein phosphatase non-receptor type 12.  
研究領(lǐng)域腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  細(xì)胞分化  
抗體來(lái)源Rabbit
克隆類(lèi)型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量88kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PTPN12:1-100/780 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

Function:
Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.

Subunit:
Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). {ECO:0000250}.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Contains 1 tyrosine-protein phosphatase domain.

SWISS:
Q05209

Gene ID:
5782

Database links:

Entrez Gene: 5782 Human

Entrez Gene: 531877 Cow

Entrez Gene: 19248 Mouse

Entrez Gene: 117255 Rat

Omim: 600079 Human

SwissProt: Q05209 Human

SwissProt: P35831 Mouse

SwissProt: Q63745 Rat

Unigene: 34723 Cow

Unigene: 61812 Human

Unigene: 319117 Mouse

Unigene: 10707 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.