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鋅指RNA結(jié)合蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN40545R
  • 中文名稱：
    鋅指RNA結(jié)合蛋白抗體
  • 英文名稱：
    Rabbit anti-ZFR Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40545R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB

  • BN40545R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱ZFR
中文名稱鋅指RNA結(jié)合蛋白抗體
別    名FLJ41312; hZFR; M phase phosphoprotein homolog; M-phase phosphoprotein homolog; zfr; ZFR_HUMAN; zinc finger RNA binding protein; Zinc finger RNA-binding protein.  
研究領(lǐng)域腫瘤  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  鋅指蛋白  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量117kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ZFR:271-370/1074 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹ZFR is 1,074 amino acid RNA-binding protein. In human, ZFR is expressed in lung, liver, lymphocytes, heart, pancreas, kidney and placenta, and regulates postimplantation and gastrulation stages of development. Murine ZFR is observed in testis, ovary and brain. With elevated levels of expression during meiosis, ZFR associates with chromosome foci in meiotic cells. ZFR contains 1 DZF domain and localizes in the somatodendritic compartment of hippocampal neurons and colocalizes with STAU2 in cytosolic RNA granules. Knockout of ZFR in mouse embryo prevents the development of some embryonic structures leads to an increase in programmed cell death with a decrease in mitotic index.

Function:
Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA.

Subcellular Location:
Nucleus. Cytoplasm. Cytoplasmic granule. Chromosome. Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules.

Tissue Specificity:
Expressed in lung, liver, lymphocytes, heart, pancreas, placenta, brain and kidney.

Similarity:
Contains 1 DZF domain.

SWISS:
Q96KR1

Gene ID:
51663

Database links:

Entrez Gene: 51663 Human

Entrez Gene: 22763 Mouse

Entrez Gene: 365703 Rat

Entrez Gene: 321659 Zebrafish

SwissProt: Q96KR1 Human

SwissProt: O88532 Mouse

SwissProt: Q562A2 Rat

SwissProt: Q6PCR6 Zebrafish

Unigene: 435231 Human

Unigene: 273496 Mouse

Unigene: 11634 Rat

Unigene: 26724 Zebrafish



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.












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