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蛛毒素受體抗體
  • 產(chǎn)品貨號：
    BN40514R
  • 中文名稱：
    蛛毒素受體抗體
  • 英文名稱：
    Rabbit anti-LPHN1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40514R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40514R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat(predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱LPHN1
中文名稱蛛毒素受體抗體
別    名Calcium independent alpha latrotoxin receptor 1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; CIRL1; CL1; CLIBA; G protein-coupled receptor for alpha-Latrotoxin; KIAA0821; Latrophilin 1; Latrophilin-1; Latrophilin1; LEC2; Lectomedin 2; Lectomedin-2; LPHN 1; LPHN1; LPHN1_HUMAN.  
研究領(lǐng)域細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  G蛋白信號  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量160kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LPHN1:201-300/1474 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Function:
Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis.

Subcellular Location:
Cell membrane. Cell projection; axon. Cell projection; growth cone. Cell junction; synapse. Cell junction; synapse; presynaptic cell membrane. Cell junction; synapse; synaptosome. Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.

Post-translational modifications:
Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus.

Similarity:
Belongs to the G-protein coupled receptor 2 family.
LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.

SWISS:
O94910

Gene ID:
22859

Database links:

Entrez Gene: 22859 Human

Entrez Gene: 788252 Cow

Entrez Gene: 330814 Mouse

Entrez Gene: 100514215 Pig

Entrez Gene: 65096 Rat

SwissProt: O97831 Cow

SwissProt: O94910 Human

SwissProt: Q80TR1 Mouse

SwissProt: O88917 Rat

Unigene: 94229 Human

Unigene: 260733 Mouse

Unigene: 10776 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

















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