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磷酸化G氨基丁酸B型受體2抗體
  • 產(chǎn)品貨號：
    BN40415R
  • 中文名稱：
    磷酸化G氨基丁酸B型受體2抗體
  • 英文名稱：
    Rabbit anti-phospho-GABBR2 (Ser884) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40415R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit,Sheep,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱phospho-GABBR2 (Ser884)
中文名稱磷酸化G氨基丁酸B型受體2抗體
別    名GABA B Receptor 2 (phospho S884); p-GABA B Receptor 2 (phospho S884); p-GABBR2 (Ser884) ; GABBR2; GB2; G protein coupled receptor 51; G-protein coupled receptor 51; GAB B R2; GABA B R2; GABA B receptor 2; GABA B RECEPTOR; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABA[[B]]R2; GABAB R2; GABABR 2; GABABR2; GABB R2; GABBR 2; Gabbr2; GABR2_HUMAN; Gamma aminobutyric acid (GABA) B receptor 2; Gamma aminobutyric acid B receptor 2; Gamma aminobutyric acid GABA B receptor 2; Gamma aminobutyric acid type B receptor subunit 2; Gamma-aminobutyric acid type B receptor subunit 2; Gb 2; Gb2; GH07312; GPR 51; GPR51; GPRC 3B; GPRC3B; HG 20; HG20; HRIHFB2099; Metabotropic GABA B receptor subtype 2; OTTHUMP00000021776; OTTHUMP00000063797; R2 SUBUNIT; BcDNA:GH07312; CG6706; CT20836; D GABA[[B]]R2; D Gaba2; FLJ36928.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量104kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human GABBR2 around the phosphorylation site of Ser783:IN(p-S)PE 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010].

Function:
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Subunit:
Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.

Subcellular Location:
ell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.

Tissue Specificity:
Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle.

Similarity:
Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.

SWISS:
O75899

Gene ID:
9568

Database links:
UniProtKB/Swiss-Prot: O75899.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

g-氨基丁酸(GABA)是哺乳動物中樞神經(jīng)系統(tǒng)中重要的抑制性神經(jīng)遞質(zhì)，在體內(nèi)通過作用于離子通道型的GABAA、GABAC受體及代謝型的GABAB受體而發(fā)揮生理功能。 GABAB 受體存在于神經(jīng)元的突觸前及突觸后部位，介導(dǎo)慢的抑制性效應(yīng)，在腦內(nèi)參與許多重要的生理活動和病理變化，包括認(rèn)知損害、癲癇、痙攣及藥物成癮等。 GABAB2在與GABAB1形成二聚體后可激活G蛋白，但它沒有結(jié)合GABA的能力；GABAB2還可增強(qiáng)激動劑與GABAB1的親和力，并且通過與GABAB1形成二聚體結(jié)構(gòu)而屏蔽GABAB1的胞內(nèi)滯留信號。























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