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纖維束1抗體
  • 產品貨號：
    BN40218R
  • 中文名稱：
    纖維束1抗體
  • 英文名稱：
    Rabbit anti-Fascin1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN40218R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Pig) 推薦應用：IHC-P,IHC-F,IF,ELISA

  • BN40218R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Pig) 推薦應用：IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱Fascin1
中文名稱纖維束1抗體
別    名55 kDa actin bundling protein; 55 kDa actin-bundling protein; Actin bundling protein; FAN 1; Fscin1; FAN1; Fascin 1; Fascin; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; Fascin1; FLJ38511; FSCN 1; FSCN1; FSCN1_HUMAN; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like (fascin homolog sea urchin); Singed like protein; Singed-like protein; SNL; Strongylocentrotus purpuratus.  
研究領域腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節(jié)因子  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Pig, )
產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Fascin1:11-110/493 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

Function:
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Subunit:
Associates with beta-catenin. Interacts with PLXNB3.

Subcellular Location:
Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. Cytoplasm, cytosol. Note=In glioma cells, partially colocalizes with F-actin stress fibers in the cytosol.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.

Similarity:
Belongs to the fascin family.

SWISS:
Q16658

Gene ID:
6624

Database links:

Entrez Gene: 6624 Human

Entrez Gene: 14086 Mouse

Entrez Gene: 683788 Rat

Omim: 602689 Human

SwissProt: Q16658 Human

SwissProt: Q61553 Mouse

SwissProt: P85845 Rat

Unigene: 118400 Human

Unigene: 289707 Mouse

Unigene: 199526 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FSCN1為細胞骨架肌動蛋白的一種，該蛋白有蛋白結合,橋連、肌動蛋白絲結合的功能。 主要參與細胞增殖、肌動蛋白細胞骨架組織和生物發(fā)生、肌動蛋白絲束形成。Fascin也是一種actin結合蛋白，它的功能是把F-actin聚集捆綁成束，與細胞的運動相關。病理情況下，各種惡性腫瘤細胞經常高表達Fascin。


















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