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β2-微球蛋白抗體
  • 產(chǎn)品貨號：
    BN40212R
  • 中文名稱：
    β2-微球蛋白抗體
  • 英文名稱：
    Rabbit anti-beta 2 Microglobulin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

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  • BN40212R-100ul

    100ul

    ￥2360.00

    交叉反應：Human 推薦應用：WB,ELISA

  • BN40212R-200ul

    200ul

    ￥3490.00

    交叉反應：Human 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱beta 2 Microglobulin
中文名稱β2-微球蛋白抗體
別    名B2M; Beta-2-MG; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Hdcma22p; B2MG_HUMAN; Beta-2 microglobin; Beta 2 microglobulin precursor; Beta chain of mhc class 1 proteins; Beta chain of MHC class I molecules; Beta-2-microglobulin form pI 5.3; CDABP0092.  
研究領(lǐng)域細胞生物  免疫學  淋巴細胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, 
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量13/27kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Beta-2-Microglobulin protein: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].

Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subunit:
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.

Subcellular Location:
Secreted. Note=Detected in serum and urine.

Post-translational modifications:
Glycation of Ile-21 is observed in long-term hemodialysis patients.

DISEASE:
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.

Similarity:
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

SWISS:
P61769

Gene ID:
567

Database links:

Entrez Gene: 567 Human

Entrez Gene: 12010 Mouse

Entrez Gene: 24223 Rat

Omim: 109700 Human

SwissProt: P61769 Human

SwissProt: P01887 Mouse

SwissProt: P07151 Rat

Unigene: 534255 Human

Unigene: 702947 Human

Unigene: 163 Mouse

Unigene: 1868 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

小鼠抗人β2微球蛋白在中樞神經(jīng)系統(tǒng)感染、腫瘤及全身性自身免疫性疾病患者腦脊液中，會出現(xiàn)β