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G蛋白/鳥苷酸結(jié)合蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN40210R
  • 中文名稱：
    G蛋白/鳥苷酸結(jié)合蛋白抗體
  • 英文名稱：
    Rabbit anti-GNB1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40210R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN40210R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱GNB1
中文名稱G蛋白/鳥苷酸結(jié)合蛋白抗體
別    名G protein beta subunit GI/GS/GT; guanine nucleotide binding protein (G protein), beta polypeptide 1; guanine nucleotide-binding protein G; GBB1_HUMAN.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量37kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human G protein beta subunit GI:101-200/341 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹G protein beta subunit GI/GS/GT (guanine nucleotide-binding protein G). WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

Function:
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Subunit:
G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2. The heterodimer formed by GNB1 and GNG2 interacts with PTH1R (via C-terminus).

Post-translational modifications:
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.

Similarity:
Belongs to the WD repeat G protein beta family.
Contains 7 WD repeats.

SWISS:
P62879

Gene ID:
2782

Database links:

Entrez Gene: 2782 Human

Entrez Gene: 14688 Mouse

Entrez Gene: 24400 Rat

Omim: 139380 Human

SwissProt: P62873 Human

SwissProt: P62874 Mouse

SwissProt: P54311 Rat

Unigene: 430425 Human

Unigene: 2344 Mouse

Unigene: 126047 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

G蛋白又稱：鳥苷酸結(jié)合蛋白，存在于全身各個(gè)組織和細(xì)胞中，G蛋白在信息傳遞中起到很重要的作用,參與細(xì)胞內(nèi)外信息的相互傳導(dǎo)。
激素受體與腺苷酸環(huán)化酶是細(xì)胞膜上兩類分開的蛋白質(zhì)。激素受體結(jié)合的部分在細(xì)胞膜的外表面，而腺苷環(huán)化酶在膜的胞漿面，在兩者之間存在一種起耦聯(lián)作用的調(diào)節(jié)蛋白——鳥苷酸結(jié)合蛋白（guanine nucleotide-binding regulatory protein）細(xì)胞受到各種刺激信息，包括化學(xué)性的激素和神經(jīng)遞質(zhì)及非化學(xué)性的聲音、圖像等。刺激信息通過G蛋白的激活作用，在胞漿中生成數(shù)目眾多的第二信使分子，產(chǎn)生十萬級(jí)放大效應(yīng)，引起細(xì)胞興奮，讓后促動(dòng)器官完成各自功能。
1977年，美國(guó)科學(xué)家阿爾弗雷德-戈德曼-吉爾曼(Alfred Goodman Gilman)發(fā)現(xiàn)了G蛋白及其在細(xì)胞興奮傳導(dǎo)方面的重要作用。1994年，吉爾曼因“G蛋白”方面的研究成果而榮獲諾貝爾生理及醫(yī)學(xué)獎(jiǎng)。